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The 10 structural models with the lowest associated energy from 100 calculated structural models were used to prepare figures using the PyMOL Molecular Graphics System, Version 2.4 (Schrdinger, LLC)

NNMT normally methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine